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The Prague International Airport (PRG) is an air gate to the Czech Republic. The airport provides daily connection from/to major European cities. Other destinations can be reached via the airports in Frankfurt, London, Amsterdam or Paris, where you have to change planes. The airport called Ruzyne is located on the northwest edge of the city. In the Arrival Terminal houses a post office, bank and exchange counters, car rental agencies counters, AVE accommodation agency counter and a restaurant. In the Departure Terminal you will find shops, restaurants, fast food and airline agencies counters. For Airport Information dial +420 220 111 111.

The town centre can be reached by cars, shuttle vans or buses, whose stops are situated in front of the Arrival Terminal:

• FIX runs cars from the airport to any place in the city. Cars are easily recognized as Volkswagen Passat sedans with a Visa Credit Card ad on the door. The driver will charge you a fixed  price for a ride to the city (from CZK 120 to 770,  according to the city zone). All cars have air conditioning and are fast and comfortable.
• CEDAZ runs shuttle vans (every 30 minutes from 6 a.m. to 9 p.m.) between the airport and the city centre for CZK 90. The ride in a comfortable van takes about 30 minutes. Tickets are available on the board.
• WELCOME Touristic Praha runs shuttle buses (every 30 minutes from 8.30 a.m. to 7 p.m.) between the airport and the city centre for CZK 95. The ride in a comfortable bus takes about 30 minutes. Tickets are available on the board.
• CITY Transport Authority runs bus No. 119 (every 10 minutes from 4.30 a.m. to 11.30 p.m.) between the airport and the Dejvicka metro station. The ride takes about 25 minutes and the bus is not comfortable. Do not forget to buy a CZK 12,- ticket from a newsstand or the yellow machine at the bus stop. At the Dejvicka metro station take the metro line A A to the city centre (without having to buy a new ticket, because your ticket is valid for  60 minutes).

Website of Czech Airports Authority - timetable

Airlines

• Aba Air , Czech Airlines, K Leti¹ti, brana c. 1 Hangar B, Prague 6 - Airport, phone +420 220 112 977
• Aeroflot, Russian Airlines, Truhlarska 5, Prague 1, phone +420 224 819 687-9
• Aerosvit, Ukrainian Airlines, Husova 5, Prague 1, phone +420 224 248 828
• Air Baltic , Latvian Airlines, Narodni 9, Prague 1, phone +420 257 532 829
• Air Canada , Canadian Airlines, Kozi 3, Prague 1, phone +420 224 810 181
• Air France , French Airlines, Vaclavske nam. 57, Prague 1, phone +420 221 662 662
• Air Lithuania , Lithuanian Airlines, Prague Airport, phone +420 220 115 042
• Air Malta , Kaprova 13, Prague 1, phone +420 222 327 285
• Air Moldova , Moldovian Airlines, Krakovska 593, Prague 1, phone +420 222 212 570-3
• Air Ostrava, Czech Airlines, Aviaticka 12, Prague 6 - Airport, phone +420 220 114 647
• Air Special , Czech Airlines, Prague Airport, phone +420 220 112 400
• Adria Airways , Slovenian Airlines, Kamzikova 6, Prague 1, phone +420 224 212 526
• Airport Services Prague, Nove letiste 2, Prague 6 - Airport, phone +420 235 366 965 
• Alitalia, Italian Airlines, Wenceslas Square 11, Palace Darex, Prague 1, phone +420 221 629 150-152
• Air Ukraine, Husova 5, Praha 1, phone +420 224 248 828
• Austrian Airlines , Aviaticka 12, Prague 6, phone +420 220 116 272-4 
• Balkan Airlines, Bulgarian Airlines, Prague Airport, phone +420 220 560 594
• Belavia, Belarusian Airlines, Tynska 21, Prague 1, phone +420 224 808 313
• British Airways, British Airlines, Ovocny trh 8, Prague 1, phone +420 222 114 444
• British Midland, British Airlines, Washingtonova 17, Prague 1, phone +420 224 239 280
• Croatia Airlines, Betlemske nam. 6, Prague 1, phone +420 222 222 235 
• CSA, Czech Airlines, V celnici 5, phone +420 220 104 111
• Delta Airlines, US Airlines, Narodni 32, Prague 1, phone +420 224 946 733
• El Al, Israel Airlines, Wenceslas Square 33, Prague 1, phone +420 224 226 624
• Eurowings, German Airlines, Prague Airport, phone +420 223 536 242
• Finnair, Finnish Airlines, Spanelska 2, Prague 2, phone +420 222 252 448
• Fischer Air, Czech Airlines, Prague Airport, phone +420 220 116 170
• Gandalf Airlines, Italian Airlines, Prague Airport, phone +420 220 115 042
• Airzena, Georgian Airlines, Perunova 16, Prague 3, phone + 420 721 739 021
• JAT, Yugoslav Air Transport, Zitna 49, Prague 1, phone +420 224 941 769
• KLM, Royal Dutch Airlines, Na prikope 21, Prague 1, phone +420 233 090 933
• LOT, Polish Airlines, Parizska 18, Prague 1, phone +420 222 317 524
• Lufthansa, German Airlines, Prague Airport, phone +420 220 114 456
• Malev, Hungarian Airlines, Na Prikope 15, Prague 1, phone +420 224 224 471
• Pulkovo Air, Russian Airlines, Krakovska 22, Prague 1, phone +420 222 210 797
• SAS, Scandinavian Airlines, Aviaticka 12, Prague 6 - Airport, phone +420 220 116 031-2
• Swiss International Airlines , Lazarska 8, Prague 2, phone +420 221 990 444
• Syrian Arab Airlines, Prague Airport, phone +420 222 322 153
• Tarom, Romanian Air Transport, Soukenicka 8, Prague 1, phone +420 222 315 076
• Tatra Air, Slovakian Airlines, Prague Airport, phone +420 220 114 115
• Travel Service, Czech Airlines, K Letisti 30, Prague 6 - Airport, phone +420 220 115 069
• Tunis Air, Tunisian Airlines, Zitna 49, Prague 1, phone +420 224 942 341 
• Turkish Airlines, Wenceslas Square 62, phone +420 221 518 386-7
• Ural Airlines, Russian Airlines, Senovazne nam. 23, phone +420 224 122 004

Train

It is easy to get to the Czech Republic from all major European cities by train. Remember, in summer the international trains tend to be full and you should book your seat at least a few weeks ahead. Most international trains arrive at Praha Hlavni Nadrazi (the Main Station). Several trains go to Praha Holesovice or to Praha Smichov or to Praha Masarykovo Nadrazi railway stations. All these stations have metro stops and are easily accessible.
The Main Station has the best facilities. There is an exchange office, an accommodation agency, showers, a left-luggage office, day-use lockers and fast food.

Website of Czech Railways (CD)

Timetable

Bus

Bus is the cheapest way to travel across Europe. The Czech Republic provides connection from/to major European cities several times a week. Most international buses arrive to Prague to Florenc (the Main Bus Station), where you can find the schedules, fares and some travel agencies. A few buses go to Roztyly. Both stations have metro stops and are easily accessible.
Timetable

By car

The Czech republic is covered with a network of generally good roads; old routes often go through villages and small towns. There are some 500 km of European-style motorways, the main ones being the D1 or E50/E65 between Prague and Brno. The traffic on motorways and country roads tends to be light. The quickest way of taking your car over to the continent is to drive to the Channel Tunnel. The most direct route from Calais to Prague is via Lille, Brussels, Cologne, Frankfurt and Nuremberg, entering the Czech republic at the Waidhaus - Rozvadov border crossing - a distance of over 1000 km. As in the rest of Continental Europe, you drive on the right-hand side of the road. The legal driving age is 18 years . The speed limit in built-up areas is 50 km/h, on major roads 90 km/h, and on motorways 130 km/h. Children under the age of 12  mustn't sit at the front seat. Drivers from the USA, Canada, UK, Australia and New Zealand need no international driving permit, only a full domestic license, along with the vehicle registration. You'll also need a certificate of insurance or "green card", normally valid for three months, showing you have full liability insurance. Your car must be equipped with a first-aid kit and a red-and-white warning triangle.

Source: http://www.czech.cz/